The Study On The Expression Of MT1-MMP,MMP-2,PRL-3,Activity Of Gelatinases And Biological Behavior Of Glioma

[Background and objective]Gliomas are the most common primary brain tumor and account for more than 40% of all central nervous system (CNS) neoplasmas. One of the main biological features of gliomas is the local invasion of its constituent neoplastic cells into the surrounding brain tissue. This invasive feature is the root cause of high incidence of recurrence . The tumor stroma and neoplastic cells coorporately contribute to invasion and metastasis, involving a series of sequential steps: adhesion degradation and migration. Degradation of extracellular matrix (ECM) and basement membrane is an important component of the process in tumor progression.This process is associated with a potential to hydrolyse ECM and basement membrane.Matrix metalloproteinases (MMPs) are particularly important for matrix degration. In this family, many studies have focused on matrix metalloproteinase 2 (MMP-2) and membrane-type matrix metalloproteinase 1 (MT1-MMP) , which is a key activator to latent proenzyme of MMP-2 (proMMP-2). Phosphatase of regenerating liver-3(PRL-3) is a new member of protein-tyrosine phosphates (PTP).PRL-3 is consistently overexpressed in metastatic tumor and represents a new therapeutic target. But up to the present, there is no report about expression of PRL-3 in gliomas.