Studies Of CLA Affect On Diabetes Rats And Its Mechanisms

Conjugated linoleic acid (CLA) refers to a group of polyunsaturated fatty acids that exist as positional and geometric isomers of linoleic acid (LA;18:2). CLA possess many physiologic properties including reduce accumulation of body fat and affect the lipid metabolism, reduce TG level and antiatherosclerosis. Besides anticarcinogenesis, CLA can improve immune function, antidiabetogenesis, antioxidant, and growth. Researchs have shown: CLA may are ligands for Peroxisome proliferator-activated receptor (PPAR), and activating PPAR. PPAR have a closed relationship with cardiovascular disease, diabetes mellitus, adiposity, tumors, and the growth and differentiation of adipocyte cells. Metabolic disorder of lipids is important for diabetes mellitus development. Increaseing free fatty acids in blood can influence insulin secretion.Leptin is the product of the obese (OB) gene, producted in adipose tissue, existence in blood. It plays an important role in the regulation of food intake, energy expenditure and reduce body weight. Our experiment is about the effects of CLA on diabetes rats, observe the changes of body weigt, serum lipids, FFA, serum glucose, insulin, leptin, and the express of leptin in rat's pancreas.