Experimental Investigation On Magnetic Labeling And In Vivo MR Tracking Of Stem Cells In Rabbits Liver

Cell transplantation is a hot spot in many fields. With the development of conceptions and techniques over 30 years, liver stem cell transplantation had been applied to clinical settings from basic research. Preliminary experimental results suggested that mesenchymal stem cells could differentiate into functional hepatocyte in vivo or in vitro. Thus, cell transplantation has a glorious prospect in the treatment of acute and chronic hepatic functional failure, hereditary and metabolic liver diseases. The application of mesenchymal stem cells instead of mature liver cells in transplantation will be a breakthrough for the treatment of liver diseases. However, in vivo image of transplant cells and further investigation would be a trouble to be faced with. Since Weissleder proposed conception of molecular imaging (MI) in 1999, MI has become the focus in radiology and relative clinical medicine Lots of researchers have labeled transplant cells with ferric oxide and many investigations to trace labeled cell have been performed with in vivo magnetic resonance (MR) imaging .In our country, such experiments were on the way. In this study, we...