The Study On Natural Antibody 3B4 Againist Infection In Vitro

The designation of natural antibodies (NAbs) is given to antibodies, circulating in normal individuals, that have been produced in the absence of overt specific antigenic stimulation.People have done many research work on its function since NAbs were found.The previous data show that NAbs play important role in the innate immunity,including oncological surveillance,autoimmunity, variant rejection, infection and so on.Natural antibodies are the first line of defence in infection,which is the earlist we know among these functions.For example Boes found that antibody-deficient mice had decreased resistance against bacteria, Zinkernagel found that natural IgM can protect organism against both bacteria and virus, Belperron found that natural IgM affects survival of the Spirochete Borrelia burgdorferi within feeding ticks.Nevertheless there are at least 2 puzzles in the related research: (1)people used to take advantage of mice deficient in antibodies and combined antibody in serum.But it is difficult to get further mechanism because of the lack of monoclone natural antibody.for example,we do not...