The Risk Factors And Outcomes Of The Development Of Vasoplegic Syndrome After Coronary Artery Bypass Graft

Background: Vasoplegic syndrome (VS) is characterized by a severe and persistent form of hypotension, tachycardia, normal or increased cardiac output, and decreased systemic vascular resistance (SVR) in early postoperation. This condition is a potentially lethal complication in patients undergoing cardiac surgery. The etiology is not completely elucidated and the clinical importance remains speculative.Objectives: The aim of this study was to identify risk factors and outcome of the development of VS after coronary artery bypass graft (CABG).Methods: Twenty-four patients who underwent coronary artery bypass grafting and developed VS were compared with 48 control patients without VS in a 2:1 case control study. VS was defined as a severe and persistent hypotension (mean arterial pressure less than 70 mmHg), occurring in the early postoperative period (within the 6 hours after operation), characterized by decreased systemic vascular resistance (indexed SVR less than 1400 dynes-s/cm~5/m~2), with normal or increased cardiac output (cardiac index more than or equal to 2.5L/min/m~2), and requiring pressor...