Clinical Implication Of Myeloperoxidase And Interleukin-10 In The Risk For Subsequent Cardiovascular Events Of Acute Coronary Syndromes

Objective: The central link of ACS was the Vulnerable Plaquefollowed by thrombus formation, which was closely correlated with inflammation reaction. Through the comparison of concentration of mediators of pro-inflammation (MPO) and mediators of anti-inflammation(IL-10), the clinic nuance in risk sratification of ACS was discussed, so as to the cross-talks of mediators of inflammation and mediators of anti-inflammation in patients with ACS.Method: 70 ACS(STEMI, NSTEMI, UAP) patients and 20 SAPpatients were selected. The concentration of hs-CRP, IL-10 were observed by the method of ELISA. The activity of MPO were detected by spectrophotometer. Statistics analysis. We determined the risk for subsequent cardiovascular events during 30 days and 3 months of follow-up, then the results were analyzed.Result: 1,The serum level of MPO, hsCRP were higher in STEMIgroup and UAP /NSTEMI group than that of SAP group(P<0.01); compared with UAP /NSTEMI group, the activity of serum MPO and concentration of serum hsCRP were higher(P<0.01) , but the concentration of IL-10 was lower in STEMI group and UAP /NSTEMI group than that of SAP group. 2,The risk for subsequent cardiovascular events were increased in patients with higher serum level of MPO and hsCRP, which was decreased in patients with higher serum level of IL-10 during 30 days and 3 months of follow-up. 3,Patients with low hsCRP and high MPO serum levels were at significantly higher risk than...