Researches And Synthesis The Drug Of Emdtricitabine (FTC) With Anti-HIV And HBV

The acquired immune deficiency syndrome is AIDS. Which is caused by human immunodeficiency virus(HIV). The hepatitis B virus(HBV) causes the Hepatitis. In now days, the human do not deal with the two dieases. So they are very harmful to the person. Although effective drugs are used in curing HIV and HBV, Which had declined the dead ratio, but the number of people infected with HTV or HBV is increasing sharply in recent years.The nucloside reverse transcriptase inhibitor(NRTIs) is one of the mechanism of anti-HIV and anti-HBV, it is a kind of drugs that had been developed for many years and there are many drugs belong to NRTIs. It had been shown that NRTIs had strong inhibiton activity with HIV and HBV. The Emdtricitabine(FTC) belongs to the NRTIs, was made by the Gilead Sciences in the USA. The Food and Drugs Administration of USA approved the Emdtricitabine to treat the infection of HIV in the July 2003, but to treat the infection of HBV is studing in the period III clinical.The FTC has the activity of anti-HIV-1 anti-HIV-2 and anti-HBV, its pharmacodynamics is similar to the Lamivudine(3TC), The pharmacodymam-ics experiment shows that the FTC was ten times to the 3TC of anti-HIV, so three times of anti-HBV. Only eat one time every day. Because of this, the FTC is concerning by the persons in the range of drugs studing and it has a very good perpection. The thesis pay a attention to the synthesis of the FTC, want to find a new synthesis route of simple technology cheap cost and easy to manufacture.The WO9214743 reports that the FTC was synthesis with...