Pharmacokinetic Study Of Osthole On Rabbit And Rat

Fructus Cnidii is the dry mature fruit of Cnidium monnier (L) Cusson, which belongs to umbelliferae and Fructus Cnidii group. According to Shen Nong's Herbal, the efficacy of osthole are warming kidney to invigorate yang, eliminating wind, depriving the evil wetness, anthelminthic acting and which was used to anandria, uterus cold, aciesis, cold–damp fluor, damp–nose lumbago and external treatment of coleitis, cunnus eczema. It was externally used in the civilian prescription to antimycoting, antiviral, expelling worm. It was demonstrated that the active components of fructus cnidiiare were osthole, imperatorin, bornylisovalerate, cnidimine, xanthotoxin, xanthotoxol, isopimpinelline, bergapten, cnidiadin, cniforina, dihydrooroselol, columbianadin etc. Osthole is the main compound and the content of which is the highest, about 0.8%, and account for 60% of all coumarins. Since the 1980's, the researches on osthole at home and abroad are mainly concentrated on pharmacology, ie hypotensive action, cardiac depression, learning and memory improving, sex hormonelike action, bone metabolism adjusting, immunity improving, etc.The researches on absorption, distribution, metabolism and...