| Objective: Salivary Adenoid cystic carcinoma (SACC) is one of the most common malignant tumor of salivary glands. It is characterized by infiltrating growth, remarkable recurrence and metastasis, which can be accounted for histology by its infiltrating capacity and distinct propensity for invasions along nerves and vessels. At present, the main method of treatment for SACC is surgery, but it is difficult to be entirely resected. Moreover, incidence of local recurrence is high after surgery. So the long-term prognosis is dismal. SACC is not sensitive to actinotheraphy, and it has poor response to classical chemotherapeutic approaches and the reaction is serious. Therefore, it focuses on investigation about SACC to explore the new therapy approach such as extracting the effective component of plants to inhibit the proliferation or induce the apoptosis of tumorous cells. Curcumin is phenol pigment extracted from the rhizome of Curcuma longa, which has been used to treat inflammatory disorders in India. Recently, the anticancer function of curcumin was found, but the mechanism remains unclear. It may be related to the inhibition of... |
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