Study Of Measuring Urinary MCP-1 Level In Steroid-treated Children With Idiopathic Nephritic Syndrome

Objective: Steroid-treatment is preferred for children with idiopathic nephritic syndrome (INS) at present, but it also brings many side effects for long-term treatment. By measuring the levels and correlations of urinary monocyte chemoattractant protein-1(MCP-1),Ⅳ-Collager (Ⅳ-C ) , N-acetyl-β-D-glucosaminidase(NAG), 24h urinary protein excretion, blood CD59 of red cellular surface and serum C3,C4 on the differently steroid-treated time of children with INS ,we study clinical values of measuring the level of MCP-1 in the urine of children with INS to guide steroid-treatment and to estimate prognosis, also to further investigate the underlying relationship between MCP-1 and the renal pathology of children with INS by several cases with a biopsy-proven diagnosis.Methods: According to the diagnostic criterion of INS there were totally 38 children with INS who had be tested. 30 newly diagnosed patients, on the base of the 8 weeks steroid-treated responses they were divided two groups: steroid-sensitive INS (SSINS)(15 patients) and steroid-resistant (SRINS)(15 patients). Additional 8 patients with a biopsy-proven diagnosis, including minimal change glomerulonephritis(2 patients), focal segmental...