Pharmacological Effects Of Antidepressant-like Activity Of YY-1 And Primary Exploration Of Its Mechanism Of Action

Depression is a chronic and recurrent mental disorder, and is recognized as one of the most common psychiatric illnesses in humans. Suicide is a major risk in depression with about 15% of depressed patients committing suicide. The main behavioral changes are low mood, negative evaluation of events, helplessness, decreased energy and concentration. How to treat depression effectively has been more and more received. Now about more than 20 antidepressants are used in clinic. Several lines of evidence suggest a relationship between monamines and depression.Objective: YY-1 has haved antidepressant-like activity clinically. Our study includes relative experiments underlying the standard for? pharmacological effects of antidepressant-like activity. Meanwhile, explore its primary mechanism of action. Methods and results:Part 1 Antidepressant-like Activity of YY-1.1 Effect of YY-1 in the Mouse tail suspension testThe tail suspension test is a widely used and well-established screening paradigm for detecting compounds with antidepressant activity. Our result showed that, compared...