Correlative Study About IgG In Experimental Autoimmune Gray Matter Disease Model

Objective: Amyotrophic lateral sclerosis (ALS) is a kind of progressive neurodegenerative disease characterized by selective degeneration of lower and upper motor neurons. ALS patients have a fatal outcome within 3-5 years. There is no specific treatment for ALS now. The cause of ALS is not known. Several hypotheses have been proposed about the aetiology of the disease, including excitotoxicity, autoimmunity, oxidative stress, neuron apoptosis, mitochondria dysfunction et al. Autoimmunity especially immunoglobulin G is implicated as playing a key role in the pathogenesis of ALS. The model of experimental autoimmune gray matter disease (EAGMD) was established in 1990 by Engelhardt, and the similar clinical symptom and pathological change were found in the model to ALS, because the model was established by immune, there is a important value to study the role of immune in ALS through the model.We established the model of experimental autoimmune gray matter disease, through the observation to the clinical change, electromyography examination , histochemistry and immunohistochemistry of animals for searching for the mechanism of the injury of the motoneuron by IgG, which may offer experimental evidences about the role of autoimmune in...