The Role Of Focal Adhesion Kinase In Regulating Cell Cycle Of Hepatic Stellate Cell

Hepatic fibrosis, of which cirrhosis is the most advanced stage, can result from chronic liver disease due to any cause. The current view envisions fibrosis as a programmed response to injury, which is dynamic and reversible. The main pathological characteristic of hepatic fibrosis is the increased and irregular deposition of extracellular matrix (ECM) components. The activation and proliferation of Hepatic stellate cell (HSC), which induced deposition of extracellular matrix (ECM) components, play a key role in the process of formation and resolution of hepatic fibrosis.The HSC proliferation is modulated by many signal transduction pathways. Focal adhesion kinase (FAK) has been indicated as a point of convergence of integrin and growth factor signal pathways. The foundation research indicates that phosphorylated FAK can make important effect on biologic behaviors of many kinds of cells, such as improving proliferation, regulating cell cycle, enhancing migration and inducing apoptosis etc. Tyr³⁹⁷ is a automatic phosphorylation site in kinase region of FAK. When Tyr³⁹⁷ is actived, it can magnify the activity of FAK by activing the rest five-phosphorylation sites of FAK in order. Therefore, we can...