Effect Of Hydrogen Sulfide On Acute Lung Injury Induced By Lipopolysaccharide And The Relationship With Nitric Oxide

Hydrogen sulfide (H2S) is a well-known toxic gas with rotten smell and its toxic effects on the nervous and respiratory systems have been extensively studied. Recently, H2S has been found to relax smooth muscle cells, by acting specifically on KATP channels, decrease blood pressure in rats and play an important role in the maintaining normal pressure. By alleviating the elevation of pulmonary arterial pressure and inhibiting proliferation of pulmonary artery smooth muscle cells, H2S has been considered as a key factor in the development of pulmonary hypertension and the modulation of structural remodeling in pulmonary blood vessel. H2S participates in the pathogenesis of isoproterenol-induced myocardial injury. Administration of exogenous H2S effectively protects myocytes and contractile activity. More and more studies shows that H2S could regulated physiological pathological processes in nervous and cardiovascular system, and H2S is known as the third endogenous gaseous transmitter following nitric oxide (NO) and carbon monoxide (CO).Acute lung injury (ALI) is a clinical syndrome with distinctively pathological changes induced by all kinds of...