The Roles Of Irbesartan In Renal Tubulointerstitial Fibrosis Of Unilateral Ureteral Obstruction

Objective: Every kind of chronic renal diseases has the same character of Renal interstitial fibrosis.The degree of renal interstitial fibrosis have correlation with the extent of renal function damage.So pepole often think that renal interstitial fibrosis can be the reliable marker to evaluate the progression of renal diseases.In the later years,the researches about cytokine are more and more. There are two kinds of cytokine in according to their effect: cytokine of promoting fibrosis and antifibrosis. Bone morphogenetic protein-7 is an important cytokine and has extensive application in department of orthopaedics.Recently some scholars find that BMP-7 connects with renal disease also.Not only it is important to the occurrence of the kidney, but also it can treat some kinds of renal diseases. So the researches about biological specificity may open up new way to treat renal diseases. Inflammatory state is another hot point. Inflammatory cells are important of it.Macrophage has the decisive significance.The degree of macrophage's collecting is related to the level of fibrosis.Macrophage's collecting is the beginning of renal interstitial fibrosis. Monocyte chemoattractant protein-1 is the most important chemokine to aspirate renal interstitial macrophage,its expression is close...