Study On Clinical Effect Of Priming Of Nonpolarized Muscle Relaxants

Objective To investigate the effect of Vecuronium, Atrocurium andRocuronium applied with priming and to evaluate the clinical feasibility of priming.Methods 90 inpatients who were to undergo operations of lower abdomen were selected for the study. The patients were randomly divided into 9 groups, among which group I, II, III were given routine injection of muscle relaxants and the others were applied priming first. Each case was injected midazolam 0.04mg/kg intravenously, droperidol 0.04 mg/kg intramuscularly, morphine 0.08 mg/kg, atropine 0.5 mg/kg prior to the operation. Fentanyl 3～4ug/kg and propofol 1～2 mg/kg were used for introduction. TOF-Watch SX acceleromyograph was turned on for calibration after the patient responded no consciousness. The strength of the evoked response to single-twitch nerve stimulation at the time (T₁) was determined 100% as a contrast (T₀). The muscle relaxant was injected intravenously from the lower limb within 5 sec after T₁ had been steady at 100% for 3 to 5 min. Intratracheal intubation was performed and the condition of intubation was evaluated when neuromuscular blockage achieved the maximum level as T₁ equaled 0. 2% procaine was infused intravenously and enflurane was inhaled, the concentration of which was adjusted according to the depth of anesthesia. Muscle relaxant was intermittently applied when T₁/T₀ recovered to 25%. The response to ulnar nerve stimulation of the adductor pollicis muscle at the wrist was recorded using the TOF-Watch SX acceleromyograph manufactured by Organon Teknika Co., Ltd.(Ireland). Indexes such as the time that muscle relaxants began to take effect, the level of the neuromusclular block at the...