Clinical Research Of Anti-myocardial Fibrosis Of Coronary Heart Disease With Blood Stasis Syndrome By Activating Blood And Removing Stasis

Coronary heart disease (CHD) is one kind of heart diseases that severely hazards human health. Myocardial fibrosis is caused by overdeposition of myocardial interstitial collagen and proportion disorder of all kinds of collagen, and it occurs in many heart diseases. So making research on myocardial fibrosis of coronary heart disease and treating it by traditional Chinese medicine is much valuable.Objective:The aim is to observe the effect and mechanism about myocardial fibrosis of CHD with blood stasis syndrome treated by activating blood and removing stasis.Method:According to prospective single blind method, 60 patients diagnosed as CHD with blood stasis syndrome were rangdomly divided into two groups:Group A (the observing group) and Group B( the control group). Each group had 30 cases. Additionally, 20 patients without blood stasis syndrome were chose as Group C, and 20 normal person were chose as Group D. Group A and Group B took the same basic treatment:Asprine 100mg qd, acertil 4mg qd , betaloc 12. 5mg bid and lipitor 10mg qd. when angina pectoris happened, nitroglycerin 0. 5mg could be put under the tougne. Furthermore, Group A was treated with XueFuZhuYu decoction for 3 weeks, while Group B was treated with placebo composed of rice sprout, malt and liguorice. Between pre and post-treating , clinical symptoms, serum procollagen III(PCIII), Lamins(LN), Hyaluronic acid (HA) , endothelin (ET), nitric oxide (NO) were compared.Results:The effective rates of Group A and Group B were 90% and 76.67% respectively, and the difference was significant (P<0.05) .Blood stasis syndrome of patients in Group A was more relieved than Group B, for aftertherapy the comparison of microscopic quantitative score in the two groups made difference significant (P<0. 01) . The level of PCIIK LN> HA and ET in two groups declined respectively, the degree of which was more obvious in Group A(P<0. 05), while the level of NO was much higher in Group A (P<0. 05). Compared to Group C, the level of PCIII> LN.. HA and ET were higher in the blood stasis group with difference significant (P<0. 05 nJc P<0. 01) , but there was no distinct difference of NO level between two groups (P>0. 05) .Conclusion: (l)Myocardial fibrosis is one pathologic state that severely influences the progosis of heart diseases.As compared with other syndromes, heart blood stasis syndrome is more relevant to myocardial fibrosis, so maybe blood stasis syndrome is the primary pathogenesis causing myocardial fibrosis. It can be treated by activating blood and removing stasis. (2)XueFuZhuYu decoction can not only treat CHD with blood stasis syndrome, but also restrain and reverse myocardial fibrosis. Besides, it can protect vascular endotheliocyte, make NO increase and ET decrease. From the other hand, it proves the effect on restraining myocardial fibrosis.