Observation On Bone Resorption Of Skeletal Fluorosis Patients

Objective To observe the bone resorption biomarkers change of skeletal fluorosis patients after detachment of high fluoride exposure for 18 years, and search after sensitive and reliable biomarkers. Methods Choose 69 cases of skeletal fluorosis patients from endemic fluorosis region and 25 cases without skeletal fluorosis as control from no endemic fluorosis region in Xinjiang. Make health examination and determine bone resorption biomarkers in their urine and serum. Results The significant difference (P<0.05) of uF, uMn, sCa, sCT, sIL-6 was found in four groups. In some groups, correlations between two biomarkers were found in statistical significant level. Conclusions High level of fluoride in drinking water can influence human bone resorption in a long term despite detaching the exposure for 18 years. The uF, sCT can mornitor the development of skeletal fluorosis. NTX, TRACP5b, OPG and IL-6 in serum may be the sensitive and reliable bone resorption biomarkers of skeletal fluorosis.