A Clinical Analysis Of 118 Cases Of Hepatic Encephalopathy

Hepatic encephalopathy (HE) is a major complication of acuteand chronic liver failure, defined as a disturbance in central nervoussystem function because of hepatic insuffi-ciency. It is characterizedby personality changes, intellectual impairment, and disturbance ofconsciousness. HE is cirrho-sis common complication and cause ofdeath .This experim-ent mostly discussed factors relating with theprognosis of HE, in order to guiding treatment.Objective and methods: To analyzed retrospectively theprognosis of patients with hepatic encephalopathy 118 case whichprimarily diagnosis were hepatic encephalopathy were selected fromthe first hospital of Ji Lin university medical college between 2000. 6and 2006.1.Results: one hundred and eighteen patients (88 male, 30 female);mean age 55.6 years;SD10.36;range 27.5-77.9 years) were selectedfor the analysis. The primary diseases included cryptogenic cirrhosis 7case, viral hepatitis B cirrhosis 64 patients alcohol abuse 8 patients.chronic viral hepatitis C cirrhosis 16patients, chronic viral hepatitis Bcirrhosis and alcohol abuse 12 patients, chronic viral hepatitis Bcirrhosis and primary liver cancer 8patients, chronic viral hepatitis Ccirrhosis and primary liver cancer 3 patients, The overall hospitalmortality was 24.57%. The factors that can precipitate hepaticencephalopathy are well recognized, andinclude infection (19.49%),gastrointestinal bleeding (14.41%), dietary protein overload (14.41%),electrolyte disturbances (5.93%) m chronic viral hepatitis B cirrhosisand alcohol abuse in 12 patients, chronic viral hepatitis B cirrhosis andprimary liver cancer (5.93%), hypoglycemia (0.85%), drinking (0.85%)emotion (2.54%), two incentives (13.56%), three incentives (2.54%)and four incentives (3.39%) The most common incentives wereinfection, gastrointestinal bleeding , dietary protein overload and moreincentives. gastrointestinal bleeding was related to the prognosis of HE.All kinds of incentives and the time to get rid of them gastrointestinalbleeding (2.90±1.7972days) infection (1.90±0.5676days) dietaryprotein overload (1.50±0.7559days) electrolyte disturbances(2.00±2.0702 days). The more incentives, the longer of time to remedy.the longest time was gastrointestinal bleeding in single incentive, andthe shortest time was dietary protein overload ,infection and electrolytedisturbances were in the midst. There were significant differences inthe time. According to the Child classification, the patients with degreeC had the worse prognosis. on the grounds of stage of HE, the patientswith stage IV had the worst prognosis.Conclusions: The peak ages of hepatic encephalopathy was30-79 years old. The major etiology of hepatic encephalopa-thy was allkinds of cirrhosis and the most common was viral hepatitis B cirrhosis.The usual inducement of hepatic encephalopathy include hepaticencephalopathy. chronic viral hepatitis B cirrhosis and alcohol abuse,viral hepatitis B cirrhosis and primary liver cancer, gastrointestinalbleeding, Child classification and the stage of HE were related with ofthe prognosis of hepatic. encephalopathy while age, sex and otherincentive were not. The more incentives, the longer of time toremedy .the long-est time was gastrointestinal bleeding in singleincentive. At presently, there is not valid method for hepaticencephalopathy, avoiding aggravating liver injury, prevention andremoval of precipitating factors and complications are the keymanagements.