| Malignant tumor is the disease charactered by excessivemultiplication and metabasis of body cells, it is result of thegenetic mutation and its genetic foundation is very complicated.With the development of cytogenetics and molecular geneticsrecently, especially the human genome project (HGP)and theapplication of the DNA micro-array, lots of information that whyand how tumour to generate and develop has been known, and manydatabases have been established. But there are redundancy and errorinformation on different scales, Consequently the specificdatabases that had dealed with the information in basic databaseshaving been built. In order to analyse, to share and to use thosebioinformation effectively, and to obtain the correlated and latestnews directly in time in the world for researchers, we try toestablish a genetic information database for Cancer, which willintegrate data analysis, data query, and data storage. Thisdatabase and its query, management system emphases the informationof tumor genetics and it will impulse the development offoundational investigation and the level of clinical treatmentgreatly.According to analyzing the requirement of this database, wefound that we could achieve this project with the databasemanagement software—Microsoft SQL Server 2000 and the utilityprogram exploitation software—Borland C++Builder. MicrosoftSQL Server 2000 is the latest edition of Microsoft , it has thefunction to decision support and the tight related integration withothers server software, it has the high-capacity of data storage,high-efficiency of data query, it's guidance and tools ofconvenient and it's user interface of friendly ,especially it'sextensibility and dependability, are all it's important insuranceof safe;C++Builder is not only a excellent exploitationsoftware, but also able to think, to analyze, to design and toprogram with the method of object oriented programming because itis base on c++ and it has the feature of powerful levis of c++. Afterthe database and its query, management system completed, user couldcall all function of this system through manipulating the main form.We try to let user manipulate conveniently as far as possible inthe aspect of form design and try to make the system more practically,almost user could complete only by click the mouse or import relateddata.We selected several related authoritative databases such asCGAP ( Cancer Genome Anatomy Project , http ://cgap.nci.nih.gov/),which is the branch of database NCBI, andNational Cancer Institute(http://cancer.gov/ cancerinformation)and Atlas Chromosomes in Cancer ( http : //www.infobiogen.fr/services/chromcancer )from more than 500 bioinformatics databasesthat have published now as the data source for the genetic·7·information database for cancer. Combined with many relatedliterature, we gathered genetic information of 288 kinds of cancer,and classed those kinds of cancer into twelve types according tohuman body system: head and neck cancer, chest and breast cancer;recirculating system cancer;digestive system cancer, centralnervous system cancer;endocrine system cancer;urinary and malereproductive system cancer;female reproductive system cancer;lymphatic and hematopoietic system cancer;soft tissue and bonetumor;cutaneous tumor;pediatric tumor and others concomitanttumor syndrome. The information of each cancer include the name ofcancer, type of system, characteristic of genetics, characteristictreatment,epidemiologic feature, clinical manifestation, pathologand staging, treatment plan aimed directly to different staging,prognosis and factors affected prognosis and so on. Moreover, wecould update and record information of new cancer or latest progressof cancer existed in the database constantly to enrich the contentof this database.The query and management system of this database involved query,record, modification, management of password and outcome forms.Query form is the main form, and we designed four ways to inquest:according to human body system, key words, chromosome andcombinative inquest. In order to make the performance simpler andmore directly, we place the frame of first outcome on this form.Three functional keys "refer", "exit", "clear" had been placedon the record form and execute corresponding function throughprogramming. And three functional keys "modify", "refer","exit" had been placed on the modification form. The textbox onrecord and modification form support the basic manipulate of cut,copy, stick, which make it easy to update. The management ofpassword form linked with the table of password of the database isthe guarantee of the database safe, the check form of password hasa textbox and a functional key "ok" and the modification form ofpassword has two functional keys "ok" and "exit" and threetextbox that the administrator can input the old and the newpassword. The outcome form will display the genetic information ofa definite cancer when user double clicks the frame of the firstoutcome.The database and its query, management system has four mostlyfunction that they are query, record, modification and managementof password. User could query a definite cancer through four ways:the first is according to the human body system, there are twelvesystems could be select from the pull-down menu;The second iskeywords query, the keywords are mostly the name of cancer and thequery system will display the corresponding names of cancer toselect for the user on the query form when you import the keywordsthat you want to search;The third is chromosome query, this wayonly needs user select the related checkbox correspond to a definitechromosome;the last but most of importance is the combinative query,it could improve the effect of query by supporting the three waysof query above at the same time. User could enter the outcome formto browse the genetic and related clinical information through thefour ways above. The administrator only needs to import the dataof cancer on the designed position when he enters the record ormodification form after imports the correct password and themanagement system will store those information into the correctposition of the corresponding table of the database. The managementof password form has the function of check and modification, whichcould avoid the damage or loss of the database that caused by theillegal user enter the system and acts without authorization.This database emphasized on the genetic information of cancerand could help researchers study the regularity of action of canceron the molecular level;and its query and management system has thefriendly interface and powerful function. Its process of query isconvenient because the user only needs to select the options orimport the keywords. The database not only has advantage of truedata, convenient operation, special content, but also is practicalby linked with related authoritative databases. It is worthextending in the research field of biomedicine for cancerThis database emphasized on the genetic information of cancerand could help researchers study the regularity of action of canceron the molecular level;and its query and management system has thefriendly interface and powerful function. Its process of query isconvenient because the user only needs to select the options orimport the keywords. The database not only has advantage of truedata, convenient operation, special content, but also is practicalby linked with related authoritative databases. It is worthextending in the research field of biomedicine for cancer. |
