Hemodynamics And Staging In Patients With Diabetic Retinopathy

Objective This study was designed to investigate the relationship between hemodynamic changes in retrobulbar vessels in patients with DM and the development of DR, using color Doppler flow imaging(CDFI) technique, and to provide valuable theories for DR Staging . Methods Altogether there were 55 normal volunteers with 110 eyes and 89 DM patients with 178 eyes including 28 patients of non diabetic retinopathy (NDR ) with 56 eyes, 32 patients of non proliferative diabetic retinopathy (BDR , fundus changes Ⅰ — Ⅲ) with 64 eyes and 29 patients of proliferative diabetic retinopathy, (PDR, fundus changes Ⅳ — Ⅵ) with 58 eyes.The ophthalmic artery and central retinal artery in these patients normal volunteers was measured with color doppler flow imaging (CDFI) technique.The peak systolic velocity ( PSV ), the end diastolic velocity ( EDV), the mean envelopet velocity (V_m) , the resitance index (RI) and the pulse index (PI) were compared. Then we processed the data with SPSS11.0 statistical package .Results compared with the control group , there was a significant increase in CRA in both PSV and EDV in the NDR group (p<0.01);the PSV,EDV and V_m in OA and CRA were significantly reduced in both NPDR and PDR group (p<0.05, p<0.01), RI and PI were inceased (p<0.05, p<0.01), the tendency became obviously with the progression of DM, and there was a statistical significance in RI in OA and PSV,EDV and RI in CRA in the three DM groups compared with each other (p<0.01). Conclusions : 1. There was a statistical significance RI in OA and PSV,EDV and RI in CRA in the three DM groups compared with each other, which provide valuable theories for DR Staging. 2. We can use CDFI to assist staging of those patients who can' t accept FFA examination.