The Study Of Embolism Factors In Pulmonary Thromboembolism

Objective:The propotion of pulmonary thromboembolism (PTE) was increased year in year out and became a major health problem worldwidely, there were a lot of risk factors of PTE but no one was specific and sensitive. This essay is to investigate the relationship between the changes of coagulation systems and PTE by examining the figures of coagulation-anticoagulation and fibrinolysis systems, as a result, the clinical basial risk factors and diagnosis of PTE were established.Methods:50 PTE patients and 50 normal control were selected and drawn 5ml venous blood. The activity of protein C (PC), protein S(PS),antithrombin -IH(AT-III), tissue plasminogen activator(t-PA), plasminogen activator inhibitor- 1(PAI-1) and lupus anticoagulant(LA) was detected by SYSMEX CA-7000 automatic coagulation analyzer. Anticardiolipin antibody(ACA) was detected by using Australia SLT.STECTRA enzyme loation analyzer and pulmonary arterial pressure by using HP 7500 color Doppler. PaO₂ PaCO₂ and P(A-a)O₂ were examined by using the United Stated NOVA M blood-gas analyzer. At last, datas were completed by using SPSS 12.0 statistical software.Results:The activity of PAI-1, levels of ACA and LA in PTE patients were significantly higher than those in the control group and activity of PC , PS, AT-IIIand t-PA was significantly lower than those in the control group and positive incidence of ACA and LA was significantly higher than those in the control group. The negative incidence of PS and PC were 50% and 44% respectively, LA positive incidence was 14%. The figures had no difference among the PTE group and the PTE combined the DVT group, spacions and non-spacions PTE, evident dangerous and non-evident factors, the activity of PS in the reset was dramatically lower than the unreset group and the difference was statistical. The activity of t-PA gentlly decreased in the reset group and the activity of PAI-K ACA and LA propotion slightly increased but the difference was not statistical compared with the unreset group. PaCh and PaCC>2 in the PTE group decreased compared with the control, levels of PAP and P(A-a)C>2 significant increased . PaCO2 of spacious PTE was lower than that of the non-spacious PTE and PAP levels in the PTE group were significantly higher than those of the non-spacious. The activity of AT-III in the PTE group had negative correlation to the age and other figures had no correlation with age-, gender and smoking.Conclusion:The activity of anticoagulation and fibrinolysis system decrease in PTE patients precuration. A lot of PTE patients may have anticoagulantion deficiency who must make further examination to find out the gene deficiency. The ACA and LA positive may be another main reason of PTE and its mechanism needs futureinvestigation. PaO2and PaCC>2 of PTE patients decreased compared with the normal control, P(A-a)C>2 and PAP significantly increase, furthermore, the level of P(A-a)(>2 and PAP have relationship with the degree of PTE. Moreover,the predisposition and characteristics of PTE are different compared with foreigners provided by this essay, so establishing a proper experiment is vital.