Study Of The Relationship Between Soluble Receptor For Advanced Glycation End Products And The Coronary Artery Disease In Nondiabetic Patients

Background and ObjectiveThe receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin super family that engages diverse ligands relevant to the pathogenesis of atherosclerosis and that is highly hyperexpressed at sites of vascular pathology. Numerous lines of evidence indicate that ligand-triggered RAGE-dependent cellular activation results in several deleterious effects, including activation of nuclear factor-κB, increased expression of cytokines and adhesion molecules, and induction of oxidative stress. The role of AGEs-RAGE interaction is deemed of great importance in diabetic vasculopathy, a growing body of evidence indicates that this signaling pathway can also play a role in nondiabetic atherosclerosis. RAGE has a secretory isofom of the receptorprotein, termed soluble RAGE(sRAGE), that may neutralize the AGEs-mediated damage by acting as a decoy. To study the relationship between sRAGE level and coronary artery disease(CAD) in nondiabetic subjects, we measured plasma sRAGE concentrations in nondiabetic patients with CAD and examined whether sRAGE level is significantly associated with CAD prevalence after adjustment for well know CAD risk factors, evaluate the correlation between sRAGE and the extent and severity of angiographic CAD in nondiabetic patients.MethodsIn 60 nondiabetic patients with angiographicaUy proved CAD and in 60 age-matched healthy controls, we measured the concentration of sRAGE in plasma, the body mass index(BMI), blood pressure, total triglycerides , total cholesterol, high-density lipoprotein(HDL), low-density lipoprotein(LDL), blood glucose,and the CAD Gensini cumulative index.Results1. The concentration of sRAGE in plasma was significantly lower (p <0.05) in CAD cases [888.52±311.45pg/mL] than in control subjects [1219.87±569.49pg/mL].2. logistic regression analysis showed sRAGE was the important risk factor in nondiabetic patients with angiographically proved CAD (OR=0.100, 95%CI 0.010-0.985, p=0.048) .3. The correlation between Plasma levels of sRAGE and the Gensini cumulative index in CAD is obvious (p=0.022) .Conclusion1. Low levels of sRAGE in plasma are importantly associated with the presence of CAD in nondiabetic patients.2. The extent and severity of angiographic CAD in nondiabetic patients was associated with plasma levels of sRAGE...