Observing And Discussing The Change Of NAA,Cho And Cr In The Brain Of Humans With Epilepsy

Background :Humans with epilepsy often have a neuronal loss and increasedcell density,so the concentration of NAA, Cho and Cr changeaccordingly.This play a important role for us to understand the pathology ofepilepsy.Objectives: (1) To observe the change of NAA ,Cho and Cr In the brain ofhumans with epilepsy. (2) Discussing the role of the change in thelocalization,diagnose and pathology of epilepsy.Objects and Methods: 56 patients with typical symptom and video-EEGmonitoring (25 patients with TLE and 31 patients with no-TLE) and 22normal subjects experienced multi-voxel 1H-MRS examinnations by locatingin the medial region of both temporal lobes with a 1.5T MRI/MRS system(CSI-se-30 , TR=1500ms , TE=30 ms). The metabolites includedN-acetylaspartate(NAA), Choline-containing compounds( Cho),Creatine andphosphocreatine (Cr) were detected.Results: The signal of NAA in patients with TLE were decreased inlH-MRS examnation,The signal intensity of NAA (1.51±0.22)and ratio ofNAA/Cho+Crin EEG abnormal area (0.55±0.11)was obviously lower than those in the contralaterals of focus(1.64±0.17, 0.70±0.16,p<0.05) and the controls(1.82±0.19, 0.776±0.10,p<0.05). The signal of NAA in patients with no-TLE were also decreased in lH-MRS examnation and the signal intensity of NAA(1.59±0.16) and ratio of NAA/Cho+Cr in EEG abnormal (0.62±0.11)area was obviously lower than those in the contralaterals of focus (1.69±0.21, 0.69±0.10,p<0.05)and the controls(1.82±0.19,0.776±0.10,p<0.05).Conclusion:Signal intensity of NAA and ratio of NAA/Cho+Cr in patients with epilepsy were decrease by lH-MRS detection .1H-MRS may help clinical dignose in patients with epilepsy.