| The main contents in this thesis include two parts:(1) the synthesis and analysis of Venlafaxine for anti-depression; (2) the synthesis and analysis of 2-fluro-2-deoxy-1,3,5-tri-O-benzoyl-α-D-arabino-furanose as the important intermediate of β-FMAU for anti-virus. Depression is one kind of psychosis associated with abnormal depressed emotion in clinic behavior. The sufferers often express strong suicide consciousness and the symptoms of lagging nerve and concomitant body. Based on the statistic informations it is estimated that the sufferers account for approximately from 3% to 5% of all population. Venlafaxine, commercially named Effexor, is a new drug of anti-depression developed by Wyeth-Ayerst and confirmed by FDA(US) in 1993. It is chemically called (R/S)-1-[2-(dimethylamino)-1-(4-methoxyphenyl) ethyl]–cyclo-octanol HCl or (±)-1-[α-(dimethylamino) metyl]-p-(methyoxyphenyl) metyl-cyclooctanol HCl, which can restrain the repetitive ingestion of the selective 5-HT and NE. Since it can cure agitated depression rapidly with few side effects, it is regarded as an effective drug for treatment of depression. Synthesis of Venlafaxine was studied based on many patents and prominently developed in this paper. The target compound was synthesized by using p-Methoxyphenylacetonitrile and cyclohexanone as the starting materials, then four steps reaction were employed, as phase transfer catalyst(PTC) substituent reaction, reduction, etc, the total yield arises at 51% and the purity reaches 98.5% detected by HPLC. Finally the chemical structure of the synthesizing molecule is in perfect agreement with those of the reference standards by liquid chromatography(LC), infrared spectroscopy(IR), HNMR, and so on. As the leading drugs for anti-virus in the near future, the nucleotides have attracted broad attention especially due to the successful research and development of several drugs such as lamivudine and acyclovir with remarkable effects. As the anti-virus drugs, quantitative structure-activity relationship (QSAR) of 2-fluro-β-D-arabifuronosyl-pyrimidine or -purine has been confirmed, which indicated that 1-(2-fluro-2-deoxy-β-D-arabinofuranosyl)-thymine (β-FMAU) owns strong activities for both anti-HBV and anti-EB in vivo and in vitro with very low toxicity to all kinds of animal models and human cells. All make it possible β-FMAU will be one safe and effective drug for anti-HBV in clinical actions. β-FMAU can be synthesized by 2-fluro-2-deoxy-1,3,5-tri-O-benzoyl-α-D-arabinofuranose as an important intermediate through simple reactions with thymine then hydrolyzed. In this paper, in order to obtain this intermediate one synthetical pathway fairly different from USPs was adopted to avoid the expensive and unavailable materials. Guanosine and inosine were respectively choosed as the main raw materials through five steps reaction, for example, protection and convertion. The final yield of total synthesis is over 17%. The content of product is over 97% before refining, then over 98.5% through refining detected by HPLC. The chemical structure of the prepared molecule is in perfect consistent with those of the reference standards by LC, IR, HNMR.
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