A Clinical Study Of The Relationship Of Hepatitis B Virus Infection In Maternal-infant Transmission After A Symphysial Immunity

Objective To investigate the relationship of hepatitis B virus infection in maternal-infant transmission after a Symphysial Immunity.Methods 100 gravidas accepted Hepatitis B immune globulin (HBIG) injection in gestation period of 28th, 32th and 32th weeks respectively. Determinate hepatitisB virus that include HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc in omphalo-blood and colostrum. Hepatitis B virus deoxyribonucleic acid (HBV-DNA)in colostrum were determinated simultaneously. All infants received HBV specific HBIG within 24 hours and at 4th weeks after birth. The hepatitis B recombinant vaccine was given within 24 hours after birth and at 1 and 6 months of age. All infants determinated HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc in 2th month after birth and infants have not obtained HBsAb 8th month after birth determinated the markers also.Results 1 infant obtained HBsAg, rate of success immunity protection is 99.00% (99/100). 92 infants obtained protection antibody HBsAb, rate of protection is 92.00% (90/100). Male rates of HBsAg HBeAg HBV-DNA rised greatly (P<0.01, P<0.001, P<0.001 respectively) in gravidas with serum PreS1(+) than in gravidas with serum PreS1(-) and protection rate of infants decreased greatly in gravidas with serum PreS1(+) than in PreSl(-) (78.79%, 98.51% respectively P<0.05). Male rates ofHBeAg> HBV-DNA in colostrum and HBeAg in omphalo-blood rised (own P<0.00\) and protection rate of infants decreased greatly (77.27%, 96.15% respectively P<0.05) in gravidas women with serum HBeAg(+) than in HBeAg(—). There were no significantly difference in vaginal delivery groups comparised to cesarean groups (P>0.05) and in breast feeding groups comparised to artificial feeding groups (P>0.05).Conclusion Symphysial immunity are helpful for the decreasing of hepatitisB virus infection rates in maternal-infant transmission and can rise success immunity rates of infants. Protection rate of infants decreased in gravidas with PreSl(+)> HBeAg(+). Vaginal delivery and breast feeding do not rise the risk of infants infection.