Significance Of Monitoring Human Papillomavirus In The Primary Lesional Area After Clinical Curing Of Condyloma Acuminata

Objective Condyloma acuminata (CA) is a common sexually transmitted disease(STD) caused by human papillomavirus (HPV) with a compavectively high recurrence after the removal of the lesion.The purpose of this study were to explore the subtypes of HPV resulting in CA,and to find the relationship of recurrence of CA with subtypes and existence status at different time points of infected HPV.Materials and Methods 96 patients of CA were consecutively diagnosed clinically and pathologically and enrolled in this study.The lesions were removed by multifunction electric knife.Fluorogenic quantitative Polymerase chain reaction (FQ-PCR) were used for the detection of HPV in the original lesion and the left-over cutanous lesional areas at the first day,3,6,9 months after the removal of the lesion.Statistical analysis were carried out to relate the subtypes of HPV and their existence at different time points with recurrence of CA.Results HPV_6,11 and HPV_{16, 18} were positive in 63 and 17 patients respectively, and mixed infection of HPV_6,11/16,18 were found in 13 cases,and both HPV_6,11 and HPV_{16, 18} were negative in 3 cases at the first time. At the 9 months after the removal of the original lesion, FQ-PCR analysis was positive in 2 of the 63 cases of HPV_6,11 ,2 of the 17 cases of HPV_{16 ,18} and 6 of the 13 cases of HPV_6,11/16,18respectivelly.No recurrence occured in patients with FQ-PCR analysis negative after 6 months.Of all the ten with FQ-PCR analysis positive at the 9 months. 1,1 and 3 recured in the 2 cases of HPV6. u,2 of HPV|6, \& and 6 of HPV6. n/i6. 18 respectively.Conclusions From this study,it can be concluded that the predominate HPV resulting in CA is HPV6. n,next one HPV16. is and HPV6.11/16.18 in order.The other type HPV could be the etiology in a small number cases of CA.The recurrence of CA is related with the subtypes and persistence of existence of the infected HPV.Cases of HPV6. 1 ] has a much better prognosis with a low recurrence compared with cases of HPV16, is and HPV6.11/16. is,which could be clue to the fact that the virus is cleaned sooner in cases of HPV6. 11 than in the latter two types of cases.Monitoring HPV by FQ-PCR in the lesional area can be used to evaluate the prognosis and recurrence of CA.