Expressions And Significance Of Survivin And BAG-1 In Breast Cancer

Objective To explore the expression of Survivin and BAG-1 in breast cancer and its relationship between the expressions of Bcl-2 and their possible roles in the development and progression of breast cancer. Methods Streptavidin-biotin peroxidase(S-P) method of immunohistochemical staining was used to detect the expressions of BAG-1, Survivin and Bcl-2 in 15 hyperplasia tissues of breast lobule, 15 simplex hyperplasia tissues of breast duct,25 dysplasia of adjacent normal breast tissue and 75 breast cancer tissues. Result The positivity rates of BAG-1, Survivin and Bcl-2 in 75 cases of breast cancer were 64. 0% (48/75) , 62.7% (47/75) and 41.3 % (31/75) respectively. The positivity rates of BAG-1, Survivin and Bcl-2 in 25 cases of dysplasia of adjacent normal breast tissue were 8. 0% (2/25) , 16% (4/25) and 24 % (6/25) respectively.In contrast, Survivin and BAG-1 were negative in 15 hyperplasia tissues of breast lobule and 15 simplex hyperplasia tissues of breast duct ,but the positivity rates of Bcl-2 in hyperplasia tissues of breast lobule and simplex hyperplasia tissues were 13. 3% (2/15) and 6. 7% (1/15) respectively.. There were no relationship between expressions of BAG-1 , Survivin and Bcl-2 and patient's age, tumour size, lymph node metastasea, or differentiation . BAG-1 expressions were located mainly in cytoplasm(26/48), partly in nucleus(15/48) and occasionally in both cytoplasmic and nuclear staining(7/48). Survivin were found mostly in cytoplasm. Bcl-2 expressions...