The Association Of P21ras Expression And Angiogenesis In Pancreatic Carcinoma And Its Clinical Significance

Pancreatic carcinoma is a commonly occurring cancer that tends to present late in its course when potentially curative surgical treatment is only possible in 20-30% patients. The tumor has a poor prognosis, with an associated 5-year survival rate < 5%. Therefore, the occurrence, invasion, and metastasis of pancreatic carcinoma are worth being investigated.Purpose: The purpose of this research is to determine the association between p21ras expression, angiogenesis and clinical pathologic characteristics. Meanwhile, a new way for pancreatic carcinoma prognostic determination was also explored.Methods: The protein expression of p21ras and vascular epithelial growth factor (VEGF), and microvessel density (MVD) were immunohistochemistrically examined in 48 cases of pancreatic ductal carcinomas and paired normal pancreatic tissues, which were surgically resected and pathologically identified. All patients were followed up.Results: The expression of p21ras and VEGF in pancreatic carcinomas are 60.40% and 64.58%, respectively; A statistical correlation was found between the expression of p21ras and VEGF (p<0.05). The results of multiple regression analysis suggested that MVD and VEGF are independent prognostic factor for post-operation pancreatic carcinoma.Conclusion: The K-ras expression and angiogenesis play an important role in the occurrence and progress of pancreatic carcinoma. The expression of p21ras seems...