Objective Probing into how to modeling the generalized linear models with the characteristics of the various clinical trial. This study provides a reference method to statistical analysis of the clinical trial. Methods Based on the instance of the clinical trial, thecharacteristics of those analyses, such as comparable analyses, influence factor analyses, treat effect analyses and repeated measurement data analyses, are shown. And infect of the orthodox statistical methods are exploded in these fields. Generalized linear models with variable modeling methods, especially with the idea of quasi-likelihood, the random effect, generalized estimating equations, solve these difficulties in the facts.Results and Conclusions The study illustrates the theories of generalized linear models. The ideas and methods are shown in the instances of the fact at those fields, such as comparable analyses, influence factor analyses, treat effect analyses and repeated measurement data analyses.
|