Study The Value Of β-HCG, Progesterone, And CK In Diagnosis And Prognosis Of The Person's Serum With Ectopic Pregnancy

Objective: To assay the value of β- HCG, P, CK in diagnosis and prognosis of ectopic pregnancy .Methods: Between 2004,2 and 2005,2, Ji Nan women and children the health care the hospital, clinical data of 42 cases of ectopic pregnancy. 30 cases of intrauterine pregnancy, and 30 cases of missed abortion were drawn vein blood 6ml, among them 24 cases of ectopic pregnancy were drawn another 2ml vein blood after 48-72 hours. Using time-discern-immunofluorescence method to assay β - HCG, chemical immunofluorescence method to assay P and kinetics of enzyme method to assay CK.Result: β -hCG in intrauterine pregnancy group were significantly higher than those of the ectopic pregnancy group (P<0. 01) and than those of missed abortion group (P<0. 01). β -hCG in ectopic pregnancy group and those of missed abortion group had no significant difference. Those 24 cases from ectopic pregnancy group were drawn vein blood again after 48-72 hours, the increase rate of β -hCG was less than 60%. Progesterone in intrauterine pregnancy group were significantly higher than those of the ectopic pregnancy group (P<0.01) and alse higher than those of missed abortion group (P<0.01),but Progesterone in the ectopic pregnancy group and in missed abortion group had no significant difference. CK in ectopic pregnancy group, in intrauterine pregnancy group and in missed abortion group had no significantlydifference (P>0. 05). To assay the relevance of 0 - HCG,P and CK. P was relevant with 0- HCG (P<0. 01). 0- HCG with CK and P with CK had no relevance. On diagnosis of ectopic pregnancy, with reference to the ninety percentile of P - HCG O - HCG<7000IU/L), P(P90=8.5ng/ ml), CK (CK> 45 ng /ml),the diagnostic sensitivity and the particularity of P-hCG ,P were higher, that of CK was lower. To use P -hCG and P together could improve sensitivity and particularity in diagnostic ectopic pregnancy, while CK together was no sense. Among 42 cases ectopic pregnancy group, 19 cases were confirm rupture by operation, CK in 15 cases of those was higher than 70IU/L, it was 78.95%. And only 5 cases in ectopic pregnancy abortion and none rupture group, it was 21.74%.Conclusion: The sensitivity and the particularity of P -hCG ,P in setting apart early pregnancy and ectopic pregnancy were higher. At the same gestational age, the increase rate of P -hCG was less than 60%.It could devide ectopic pregnancy from intrauterine pregnancy,but it was lower in deviding ectopic pregnancy from missed abortion. CK, as an enzyme factor, could not be used in diagnosis of early ectopic pregnancy, because of its lower sensitivity and the particularity. But CK could help deviding ectopic pregnancy rupture from none-rupture. So testing CK could decrease the rate of ectopic pregnancy rupture. P and 3 -HCG was relevant in diagnosis of ectopic pregnancy, to assay them together could increase the sensitivity and the particularity of diagnosis, but adding CK test could be no use.