The Effects Of Remifentanil On Serum β-EP In Patients Undergoing Craniotomy

For patients undergoing craniotomy, it is desirable to have stable and easily controllable hemodynamics during intense surgical stimulation. However, rapid postoperative recovery is essential to assess neurologic function. Remifentanil, an ultra-short-acting mu-opioid receptor agonist, may be the ideal agent to confer the above characteristics. Objective: To investigate the effects of remifentanil on serum β-Endorphin undergoing craniotomy. Method: Forty ASAâ… -â…¡patients undergoing craniotomy were randomly divided into two groups (n=20): group F as a control group and group R as a study group. All patients received general anesthesia. In group R anesthesis was induced and maintenance with propofol-remifentanil which was stopped at the end of operation. The velocity of remifentanil was set at 0.2μg·kg^-1·min^-1 during induction and 0.1μg·kg^-1·min^-1 during maintenance. In group F anesthesis was induced and maintenance with propofol-fentanyl which was stopped at the 30min before the end of surgery. ECG,SBP,DBP,HR,P_ETCO₂,SpO₂ was monitored during anesthesia. Blood samples were collected from arterial vein at different time points including before induction, 5 minutes after intubation, 60 minutes after operation, 120 minutes after operation and 10 minutes after extubation. The general condtion at the same time...