| Objective It has been shown that renal injury induced by high energy shock wave (HESW) related to the generation of oxygen free radicals and the release of endothelin-1. Taurine had the protective effects on the injury organs, such as heart, brain and kidney. The purpose of this study was to evaluate whether the taurine had the effects on the renal injury induced by HESW and evaluate its capabilities to scavenge oxygen free radical and to inhibit the release of endothelin-1. Methods Twenty male adult New Zealand white rabbits were divided into the taurine (n=10) and the control group (n=10) at random.Both groups were exposed to 1,500 shock waves at 12.75kV. The taurine group received taurine(150mg/kg) injection before ESWL while the control group received normal saline. Blood and urine sample on 1 day before and 1,3,7 day after ESWL were collected to determine level of MDA,SOD in serum and ET-1 in urine. All animals were endowed and their kidneys were examined under light and electron microscopy on 8 day after ESWL. Results There was no significant different in serum level of MDA, SOD and urinary level of ET-1 before ESWL in both groups (P>0.05). After ESWL, there was a significant increase in serum level of MDA and urinary level of ET-1 and significant decrease in serum level of SOD in the control group (P<0.05), but no significant change in serum level of MDA,SOD and urinary level of ET-1 in the taurine group (P>0.05). The histopathologic alterations in kidney were slightly mild in the taurine group compared with the control group. Conclusions Our study demonstrates that taurine has the protective effects on kidney from the injury induced by HESW in rabbits, in which the mechanism may be related with its capability of antioxygenize and effects to inhibit the production of ET-1. |
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