| In this paper, applying the theory of TCM and integrated traditional and western medicines, the pathogenesis of juvenile rheumatoid arthritis(JRA) in active stage is approached systematically from theoretical,clinical and experimental aspects . Research suggests that heat, blood stasis and toxin obstructing the meridians and invading the joints of limbs is the main pathogenesis of JRA. The main therapeutic method has been set up which is to clear away heat,relieve the toxin, eliminate dampness, remove the obstruction in meridians, activate the blood and disperse stasis, Accordingly,Qingbi and MTX Group is produced to apply as observe group,contrasting with MTX as control group ? 50casgs have been observed in the clinical study. The result proves that the therapy of clearing away heat and relieving the toxin could improve the clinical symptoms,signs and laboratory examinations . The effective rate of observe group is 76.67%, which is significantly superior to that of the control group(45.00%, P<0.05). The operating mechanisms of this therapy includes inhibiting inflammation,regulating immune function and so on.
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