Studies On The Polymorphisms Within Glutathione S-transferase And Haemotological Neoplasias

[Objective] To investigate the relationship between genetic polymer-phisms in GSTT1, M1, and P1 and susceptibility to haemotological neopla-sias (HNs) . And the association of GSTs polymorphisms with survival of chemotherapy in Adult Acute Leukemias (AALs). [Methods] As a case-control study,we investigated whether the polymorphism of GSTs gene has an association with the development of HNs using a PCR. Kaplan-Meier method and Cox Regression was utilized for analyzing the relationship between GSTs polymorphisms and the death risks among AALs patients with chemotherapies. [Results] Individuals with the GSTM1 null genotype were at higher risk of HNs.And no difference was found in the prevalence of GSTT1 , P1 allele genotype between patients and the controls. The variant GSTP1-105 genotype may be a protective factor against HNs. The polymorphism of GSTs gene had no significant RRs of death among all the patients. [Conclusions] These results imply that GSTM1 gene delete may be a genetic susceptibility factor involved in the development of the HNs. The polymer -phisms of GSTs were no associated with the higher risk of death among AALs patients with chemotherapies.