Isolation And Structure Modification Of Mangiferin From Anemarrhena Asphodeloides Bge

Diabetes mellitus ( DM ) is severely harmful to human health. In order to look for new antidiabetic compounds, we have improved the method of isolating mangiferin and studied on structure modification of mangiferin. With mangiferin as the lead compound , twenty-one mangiferin derivatives were synthesized, and their structures were all confirmed by IR, ¹HNMR, ¹³CNMR, and MS etc. Twenty of them are first reported. Preliminary screening of twenty-one target compounds, most of them can inhibit protein tyrosine phosphatase 1B ( PTPIB ). Meanwhile, three compounds having high antidiabetic activities were screened out. This suggests that mangiferin derivatives perhaps show antidiabetic activities by inhibiting PTPIB.