Study Of The Expression Of COX-2 In Gastric Cancer And Its Relationship With Angiogenesis By Tissue Microarray

IntroductionGastric cancer is one of the malignant tumors, the incidence and mortality are increasing. The unlimited growth and metastasis of tumor cells is the most important feature. It is the major reason for gastric cancer patients' failure to be cures and dead. The growth and metastasis of tumors are regulated by many factors.Tissue micoarray/tissue chip is a newly developed array - bases high throughput technique with a conspicuous characteristic of small volume rich in information that facilitates gene expression investigation of very large numbers of tumors simultaneously. It is suitable to immunohistochemistry, DNA or RNA in site hybridization with high efficiency and flexibility, and its results are highly u-niform with remarkable credibility and comparability. Many reports have demonstrated that tissue microarray/tissue chip is a new powerful technique in pathology of tumors investigation.COX -2 is a key enzyme in PG biosynthesis. Recently, an enhanced expression of COX - 2 has been found in cases of colon caner and other tumors, and NSAIDs can reduce the risk of colon cancer in animal models. Many research suggested that the tumor growth periods include the angiogenesis period. COX — 2 has tight relationship with gastric carcinogenesis, but the actual mechanism is not known.ObjectiveTo explore the expression and clinicalpathological significance of COX - 2 and MVD immunohistochemically on carcinogenesis of gastric cancer by tissue...