Clinical Study About Myocardial Infarction Patients Taking RAS Blockers For One Year

ObjectiveObserve cardiovascular protective effect of RAS blockers for myocardial infarction which emphasize on the effect to hemodynamics, blood chemistry, ventricular remodeling and cardiac function, and then discuss the related mechanism.MethodEnroll 24 patients with myocardial infarction history and give them different RAS blockers (Telmisartan and/or Ramipril) for one year's following up. During this period, hemodynamic and blood chemistry indexes are detected at the beginning, the 1st month, 2nd month, 6th month and 12th month; by the way, echocardiograph indexes including IVST, LVPWT, LVDd, LVEF, LVSEV and E/A ratio are detected at the very beginning and the 12th month.ResultBlood pressures descend within the 1st month (P<0.05) and descend significantly at the 2nd month (P<0.01); heart rate and blood chemistry indexes show no significant difference between each period (P>0.05).As for echocardiograph indexes, LVEF significantly increase and LVSEV significantly decrease at the 12th month compared with the data at the beginning (P<0.05); yet the other echocardiograph indexes only have the tendency to decline (P>0.05).ConclusionRAS blockers can decrease blood pressure steadily and effectively, improve cardiac function and inhibit myocardial remodeling in some degree.