The Analysis Of Early Related Factors Associated With Outcome Of Severe Acute Pancreatitis

Background Severe acute pancreatitis is a common disease causing by complicated pathogeny.And the mortality are very high.Althoug the pathophysiology and therapy of severe acute pancreatitis have made great progress,the mortality of patients with severe acute pancreatitis are 15%-40%. There are lots of reports about how to predict the prognosis and evaluate severity of severe acute pancreatitis. And there are also lots of criterions made to identify severe acute pancreatitis and mild acute pancreatitis. But some items can't be got early to predict prognosis such as Ranson criterion. Some items such as C reative protein, α₂ macroglobulin which can predict prognosis are not routine. At present it is lack of simpler and more accurate criterion which can predict the prognosis of severe acute pancreatits.Objective To make clear which factors are related with death of patients with severe acute pancreatitis and look for the risk factors of death of patients with severe acute pancreatitis within 24 hours after admission.Methods 60 patients with severe acute pancreatitis who were admitted from Jan. 2000 to Dec. 2003 were divided into two groups , death group 21 cases and survive group 39 cases. Clinical and laboratory data within 24 hours after admission of those patients were analyzed retrospectively.Results There are very significant difference between two groups in average age, breath rate in admission, urine volume writhin the first 24 hours after admission, creatinine, arterial pressure of O₂ (P<0.01), heart rate in admission and defaecation or not within 24 hours after admission, blood sugar, albumin,arterial pH are statistic significance (P<0.05) , but mean arterial pressure, blood amylase and urine amylase, white blood cell count,haematocrit, platelet count, blood fat, liver function, electrolysis, man and woman's proportion do not have significant difference between two groups.Conclusions the age, breath rate in admission, urine volume within thefirst 24 hours after admission, creatinine , arterial pressure of O2, heart rate, blood sugar, albumin, arterial pH, defaecation or not within 24 hours after admission are the related factors of death of severe acute pancreatitis.