| Purpose To observe the effect of fresh amniotic membrane transplantation (fAMT) on various kinds of ocular surface disease. Material and Methods fAMT and, or combined with limbo-corneal transplantation (LT), LT were operated on 93 cases, 103 eyes with different kinds of severed ocular surface disorders (primary pterygium 27cases, 31 eyes, recurrent pterygium 31 cases, 36 eyes). Results By fAMT for reconstruction of conjunctiva fornix, 72.7% cases were successful, 18.2% cases were partial successful, 9.1% cases failed. In comparative study between fAMT and LT, recurrences occurred in 6 cases (6/23, 26.1%) in fAMT group and in 3 cases (3/22, 13.6%) in LT group in the treatment of pterygium. Pterygium recurrences occurred in 5.6% cases by fAMT combined with LT in the treatment of recurrent pterygium. Reducing corneal revascularization and promoting epithelial healing were observed in the treatment of ocular surface burns and surface disorders. Conclusions Amniotic membrane transplantation may restrain corneal revascularization and promote corneal epithelial healings in the treatment of ocular surface disorders. Amniotic membrane transplantation is a good method for the conjunctiva fornix reconstruction in the treatment of symblepharon. Amniotic membranetransplantation combined with limbal transplantation is an effective method in the treatment of corneal limbal deficiencies.
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