Experimental Study Of Effects Of Modified Modified Polypori Umbellati Decoction On Rats With Mesangial Proliferative Glomerulonephritis

Mesangial Proliferative Glomerulonephritis (MsPGN) is character as Mesangial cell proliferate slightly and diffusely, and ground substance of mesenterium proliferate moderately, while glomerular capillary wall normally. It is one of most frequent type of chronic glomerulonephritis, take 24.7-41.5% of renal biopsy of patient in China. The morbidity rate of children is almost a half.The significance of studyMsPGN is one of most common patho-type of primary glomerulopathy, it is very dangerous because of the high incidence rate. Further more, modern medicine is lack of effective treatment at present. It is a important way to use Traditional Chinese medicine to treat MsPGN.The pathway to studyThis topic discover the direct relation between pathological type of MsPGN and differentiation of symptoms and signs for classification of syndrome: the pathogenesis oftraditional Chinese medicine of MsPGN is damp-heat gluing each other andym-asthenia,which can be treated by Modified Polypori Umbellati Decoction effectively, so we put forward the hypothesis that use the adding Modified Polypori Umbellati Decoction to treat MsPGN according to the theory of traditional Chinese medicine, if succeed through experiment of animal and clinical, we will develop a new traditional Chinese drugs to treat MsPGN effectively. Further more ,we find the significance level which can pathological process of and prognosis of MsPGN. So it have extensive prospect and will give us substantial social and ecnomic benefits.The contents of studyThis topic mainly is about the Modified Polypori Umbellati Decoction having thePharmacodynamics effects on MsPGN, including the pathological structure of nephridial tissue, and renal function including serum creatinine , urea nitrogen and urea nitrogen hyperproteinuria; and hemorheology including the packed red cells, blood sedimentation rate, whole blood high incide specific viscosity, whole blood short incide specific viscosityand blood plasma specific viscosity,etc; and the cytokine including IL-6 >> TNF- a and IL-1 3-The findings of studyWe can see from the results of study:1. Compared with the normal group, the group of pathological model of rats' intercapillarycells proliferate obviously and the diameter of renal glomeruius augment significantly, which is in line with the pathological change of MsPGN of mankind, so we can see the modelings are succeed. Forthermore, the groups of therapy comparing wih the group of pathological model, the intercapillary cells and the diameter of renal glomeruius are decrease, while there is no variability between each group of therapy.so we draw the conclusion that the Modified Polypori Umbellati Decoction have the same effect with Low Molecular Heparin in curing the MsPGN.2. Compared with the normal group, the group of pathological model of rats' osmotic erythrocyte are obvious, and most are multiformity, hint that glomerular basement membrane damaged heavily. But after being treated by Chinese medicines groups, theconditions get better. The Low Molecular Heparin however can improve the conditions,havenot the meaning of statistics. So we can draw the conclusion that The Low Molecular Heparin can inhibit the proliferation of intercapillary cells, have little effects on thehematuria, the mechanism is still on study.3. Compared with the normal group, the group of pathological model of rats' Urine protein is increase obviously, so the filter membrane of renal glomeruius damaged heavily. However, after being treated by Chinese medicines groups, the conditions get better, The Low Molecular Heparin can decrease the Urine protein, but the effects are not better than the TCM groups.4. Compared with the normal group, the group of pathological model of rats' serum creatinine increase significantly, the renal functions are hurt heavily. The Chinese medicines groups especially the middle dosage and the group of Low Molecular Heparin can decrease the serum creatinine so as to improve the renal function. However the lower and higher groups have little evidence prove the truth that can make renal function better.5. Compared with the normal group, the group of pathological model of rats' urea nitrogenincrease significantly, the renal functions are hurt heavily. Both the Chinese medicines groups and the group of Low Molecular Heparin can decrease the urea nitrogen so as to...