ATPase Activities Of Cardiac Muscle Tissue In Rats With Acute Organophosphorus Poisoning And The Effects Of Magnesium Sulfate On Them

Objective: To investigate the mechanism of cardiac muscle injury by organophosphorus through observing the ATPase activities of cardiac muscle tissue in rats with organophosphorus poisoning and the effects of magnesium sulfate on them in our study. Methods: 30 healthy rats were randomly divided into three groups, that is, group A(control), group B(oxide dimethoate was given intraperitoneally), group C(magnesium sulfate was administrated prior to the use of oxide dimethoate). The activities of Na~+-K~+-ATPase, Mg~2+-ATPase and Ca~2+-ATPase of cardiac muscle tissue were measured respectively, then comparisons were made among three groups. Results: The activities of Na~+-K~+-ATPase, Mg~2+-ATPase and Ca~2+-ATPase were decreased obviously in group B as compared with group A (P<0.01) . The activities of Na~+-K~+-ATPase,Mg~2+-ATPase and Ca~2+-ATPase recovered in various degree in group C as compared with group B. The activities of Na~+-K~+-ATPase, Mg~2+-ATPase recovered (P<0.01) more obviously than Ca~2+-ATPase activities (P<0.05) . Conclusions: The activities of Na~+-K~+-ATPase, Mg -ATPase and Ca -ATPase of cardiac muscle tissue were inhibited when rats were given oxide dimethoate. Magnesium sulfate preparation can reduce the inhibition to ATPase, especially to Na~+-K~+-ATPase and Mg~2+-ATPase.