| Objective: Femoral head ischemic necrosis has been a kind of common disease in clinic. There are various of therapy including: traditional Chinese medicine (TCM) and traditional Chinese drug, Surgery and Vascular endothelial growth factors, et al.All of these aim to promote the blood circulation of femoral head, precaution and treatment femoral head collaps, allevate and eliminate the pain of hip join, then recover the function, But all of these aren't satisfied. The administration of lumber sympathetic ganglion block (LSGB) has a fairy long history which purpose is to vesodilate, increase the blood volume, elevate the oxegen supply, remit pain, decrease stress and regulate bonemetabolism, then accelerate the repairation. But up to now, there have been no reports on this subject at home and abroad yet. This research purpose is based on that theory background above, observe LSGB treatment effect and postoperation matters to femoral head necrosis and probe into its function mechanism and to lay the experiment basis for the repairation of femoral head ischemic necrosis in clinic. Methods: Seventy two mature Japanese rabbits of either sex weighing 2.5±0.3kg, aged 4±0.1months were randomly divided into three groups with 24 rabbits in each group: the LSGB group (group A), the normal saline group (group B)and the control group (group C). After raised one week, group A and B rabbits were aneathesized by injecting 0.3% pentobarbital sodium (1.0 ml.kg-1) into auris vein, fixed by spine position,denuded at back, disinfected, referring to the method of Yangshuhua prepare femoral head necrosis modal: operate a lateral incision in the right hip joint, expose and dislocate the femoral head, then packed six times with the cotton stick after infiltrated liquid nirtogen, which continued two minites. Reposited after rewarming with bland salin, then sew the incision demixingly, No treatment in group C. After the first operation is completed, referring to the luanjingyuan,s method to prepare the LSGB. 0.5cm beside the right to T12～L1 septum operated a longitudinal incision, separated the muscle to intertransvers ligament, cut the L1 transverse process with bone-cutting forceps, insetted the epidural catheter along the sympathetic nerve chain about 1cm and fixed the catheter on the L2 transverse process and the muscle around, the other end of the catheter punctured out from the back skin, remained about 6cm so as to infuse medicine. Postoperation intramuscular infection penicillin 40 million u/day to prevent infection, which continued 3 days. After three days since surgery, once a day, through the catheter infuse 0.25% bubikayin 1ml in group A. In group B infuse saline 1ml once a day, and did nothing to C group. Before preparing the modal of femoral head necrosis monitored the map of femoral artery blood flow with colordoppler as baseline. In the third day after surgery, the end of the third week and the fifth week, fifteen minites after infusing 2.5%bubikayin to group A and 0.9% soline to group B monitor the map of the blood flow, and continued 3 times. Recorded the value of the maximal blood flow velocity (Ma), the minimal blood flow velocity (Mi) and vascular risistance index (VRI), averaged out all the value, operated the above step to group C in the same way at the same time. At the second day, the forth week, the sixth week, vidicon the double hip joint centric position to observe femoral head repairation. Then killed the rabbit, took out the femoral head, divided into two parts along coronal section. The front half of femoral head were put into 10% formaldehyde liquor to fix, decalcificated, dehydrated, embed with olefin, seriate slice with microtome, did HEstaining, observed the histological changes of femoral head under optic microscope and counted the empty lacuna.Infused the slice to distilled water after olefin was removed and stained with Factor VIII related antigen, through optic microscop selected 10 high power fields, then counted capillaries. The other half of femoral heads were carried biomechanical test, to measure the anti-pressure sthenth and the elastic modulus. Result: Compared with before LSNB,Ma and Mi in group A quickend significantly (P<0.01), VRI diminished significantly(P<0.01). Compared with group B and C, the thirdday, the end of the third week and the fifth week after injection the Ma and Mi in group A quickend obviously (P<0.05),and VRI lowerd significantly (P<0.01).The Ma,Mi and VRI in group B and C and between group B and C had no significant difference all the time (P>0.05). The scores in group A and B had no difference at different time (P>0.05). Compared with the end of the second week after injection, at the end of forth and sixth week the scores had notable changes in group B (P<0.01). Compared with group C, the scores in group A and B notably increased at the end of the second,forth and sixth week (P<0.01).There was no difference between in group A and B at the end of the second week(P>0.05),the score in group B was much higher than that in group A at the end of the forth and sixth week (P<0.01). Compared with group C, the empty lacuuma in group A and B increased significantly (P<0.01) while at different time there were notably more empty lacuuma in group B than that in group A (P<0.05). Compared with the end of the second week, the empty lacuuma were gradurly reduced at the end of the forth and sixth week (P<0.05orP<0.01), and gradualy increased in group B (P<0.05orP<0.01). Compared with the end of the forth week, there were much more empty lacuuma in group A while less in group B (P<0.05). And at the end of the second week, the most margin of cartilage layer in group B had immunodeficiency, the arrangement of cartilage liver disappeared. The adipose cell splinterd and the blood cellsreduced in the marrow cavity. While in group A part of the cartilage layer margin had immunodeficiency and the arrangement of cartilage liver disordered. At the end of the forth week there were a great of osteoblast, fibroblast cells and capillaries proliferated in marrow cavity in group A, while in group B few of them proliferated. At the end of the sixth week in group B the necrosis bone trabicula collapse or became dedicated while a great of neoformative bone formatted along the necrosis bone trabicula in the A group, the bone trabicula widened. There was no significant difference in group C at different times (P>0.05). At the end of the second week after injection the blood filled bad, and the region of rarefaction or no capillary expanded in both group A and B, and the number of capillaries significantly less than that in group C (P<0.01), but there were notable more capillaries in group A than in group B(P<0.01). Compared with group B, the number of capilliaries significantly increased, but still less than group C (P<0.01). Compared with the end of the second and forth week, the capillaries obviously accrued in group A (P<0.01) and obviously decreased in group B(P<0.05), there was no significant difference in group C(P>0.05). Compared with the end of the second week, the capillaries in group A increased (P<0.05) and there were no difference in group B and C at the end of the forth week (P>0.05). The anti-pressure strength had no difference in three groups (P>0.05) at the end of the second week after injection. There...
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