Changes Of Serum Thrombopoietin Level In Patients With Aplastic Anemia And Acute Leukemia

PrefaceThrombopoietin (TPO)is megakaryocyte growth and development factor. It was found in 1958. It was coloned at first by De Sauvage in 1994. Many people began to do a lot of researches on it after that. They found that serum TPO levels was very valued on experting persons and directing cure . To measure serum thrombopoietin (TPO) levels in thrombocytopenic conditions of aplastic anemia (AA) and acute leukemia ( AL) and explore the clinical significiance of the changes of TPO levels.MethodsSerum TPO concentration was determined in AA ( n = 25 ) , AL( n = 50) (These people were devided in two parts by wheather accepting chemotherapy or not , every part was 50% ,n =25) and normal controls ( n = 15 ) by using an enzyme - linked immumosorbent assay ( ELISA).ResultsSerum TPO level in AA patients was much higer than that in normal con-trols[ (1864. 63 356. 66pg/ml) Vs(84. 23 14. 90 pg/ml) ,P <0. 01 ] ;and serum Tpo level in AL which accepting chemotherapy ago was much higer than that in normal controls[ (233. 50 57. 89 pg/ml ) Vs(84. 23 14. 90 pg/ml ) ,P <0. 01 ] ;and in those after the end of chemotherapy was (944. 55 258.48 pg/ml) , (P <0. 01) ;and the later was much higer than the before ( P <0. 01). The serum TPO level in A A patients was much higer than that in AL. [ (1864.63 356. 66 pg/ml) vs (589.02 404.16), P <0.01 ]. Furthermore,there was an inverse correlation between TPO concentration and platelet count in AA and AL pations( AA = -0.994, AL(before) = -0.961 , AL(after) = - 0. 979 P < 0. 01). There was the same conclusion between TPO concentration and megakaryocyte in bone marrow (AA = -0.844, -yAL = -0.931 , P<0.01).ConclusionSerum TPO level was regulated by platelet count and megakaryocyte in bone marrow . It is high in thrombocytopenia due to thrombopoietic failure.