A Study On An Evaluation Of A Cardiac Reserve Measurement Method Based On Cardiac Vibration Signal And Its Applications

The most important aspect of cardiac dysfunction in heart failure was not the depressed cardiac performance noted at basal resting states, but rather the loss of cardiac reserve. It is this diminution that represents the extent of its failure and needs to be measured. The loss of cardiac reserve leads to poor prognosis and inability to cope with stress, such as exercise or septicaemia. An important objective of treating heart failure is to preserve and if possible improve cardiac reserve. Cardiac reserve is a major determinant of exercise capacity, and especially, superior cardiac function is required by athletes to sustain their physical prowess. It is therefore essential to develop a non-invasive method to allow serial measurements of cardiac reserve.Based on the research on relationship between cardiac contractility and heart sound, this project intended to study the relationship between cardiac contractility variability and heart rate variability, noninvasive method for evaluating cardiac reserve and its clinical application,contributing to development of a method, which can offer the advantages of being noninvasive, convenient, inexpensive, rapid, simple and easy, objective and quantitative, repeatable, high sensitive and specific. Author studies included ROC curve and likelihood ratio in evaluation of two noninvasive indicators of cardiac reserve for evaluating cardiac function, A Study on Clinical Applications of Exercise Cardiac Contractility Monitor in Contrast between Right and Left Ventricular Function, a study on 6-minute walk test incorporating cardiac contractility change trend and heart rate change trend measurements and its clinical applications, Particularly, through the studies above, we presented a concept and method for, incorporated more directed method for measuring cardiac reserve into 6-minute walk test and expanded 6-minute walk test into a 6-minute exercise test.Author participated in several population based surveys of cardiac reserve, through statistical analysis, has observed a very significant differences in cardiac contractility change trend between patients with cardiovascular diseases and healthy subjects, as well as athletes and ordinary population; studied the feasibility of noninvasive method for measuring cardiac reserve use at bedside, in a clinic, and at home; preliminarily practiced the important thought of large sample and multiple centers in evidence-based medicine.