Clinical Analysis Of 69 Cases Of Myelodysplastic Syndrome

Objective: To Study and analyse clinically 69 cases of myelodysplastic syndromes (MDS). Methods: The general condition,clinical and laboratory features, and therapy of these patients from Jan.1990 to Dec. 2002 were studied and Retrospective analysis was used. Results: 33 cases (47.8%) were less than 40 years old . 68 cases(98.6%)and 24 cases (34.8%) developed anemia and pancytopenia respectively at diagnosis. Bone marrow aspirate smears showed erythrocyte dysplasia in 91.2% of these patients and granulocytic dysplasia in 34.8% of these patients ,respectively. Bone marrow biopsy specimens showed ALIP (abnormal locatization of immature precursors) in 45.4%(15/33) of patients .The level of hemoglobin in 62.5% of patients with refractory anemia (RA) and refractory anemia with ringed sideroblasts (RAS) was increased during ordinary therapy whereas the most patients with refractory anemia with excess of blasts(RAEB), refractory anemia with excess of blasts in transformation(RAEBT) was poor. Conclusion: Bone marrow aspirate combined biopsy could improve the diagnosis of MDS.Anemia in patients with RA and RAS can be improved by ordinary therapy,but how to treat RAEB,RAEBT and how to protect against MDS' transformation are going to be further studied .