| Objective: The aim of the study was to examine whether the quantitative gated single-photon emission computed tomography (QGSPECT) can give the useful information of assessing to the heart function, including to ejection fraction cardiac output or the right ventricular size, and to assess the correlation between gated single-photon emission computed tomography and echocardiography in patients .Methods: 226patients( 132males, 94 females; meanage, 49.5+/-35.5 y) wereexamined by gated single-photon emission computed tomography and echocardiography, which were at intervals of 48 hours. There were 84 patients assessed to ejection fraction (EF), 139 patients assessed to cardiac output (CO) and 83 patients measured the right ventricular size by both techniques. Technetium-99m MIBI myocardial perfusion tomography (SPECT) was performed for the right ventricular size and 201TL gated SPECT for the left ventricular function . All values that we got by SPECT were compared with that by echocardiography. The values of two different ways were compared using linear regression in all sample for every variable that we studied. Their correlation coefficients were calculated in all and apart of every variable . When studying the agreement of the consequence about right ventricular sizes assessed by both techniques, we compared agreement of them using statistical analysis (Kappa value).Results:(1)Study for the left ventricular (LV) function(1)Ejection farction (EF): LVEF values assessed by QGSPECT in all 84 patients was strongly correlated to that of assessed by echocardiography ( Y= 4.493+0.944 X, r = 0.738 , P=0.000). All 84 patients was divided into two groups (groupl: EF<50%; group2: EF50%) for their heart function assessed by echocardiography . Changes of LVEF value assessed by QGSPECT were more strongly correlated with that byechocardiography in group 1 ( r= 0.709, P =0.000< 0.001 ), but less in group 2 (r =0.343, P = 0.007< 0.05). Paired Samples Tests were performed too (P=0.555, P=0.286,respectively).(2) Cardiac output (CO):CO assessed by QGSPECT in all 139 patients was correlated well to that by echocardiography (Y=1.264+0.431X,r=0.628, P=0.000<0.001). All patients were divided into five groups basing on their heart function (group 1: normal ; group 2:class I ; group 3: class II ; group4 : class III; group 5: class IV). In all groups, there were great difference between the date from QGSPECT and those from echocardiography (all P=0.000). Except class 1 and class 2 group, there were significant correlations between them (r=0.753, P=0.000; r=0.445, P=0.008; r=0.379, P=0.019; r=0.912 P=0.005; r-0.886 P=0.001, respectively). (2) Study for the right ventricular (LV) sizeAll 86 patients checked by 99mTc -MIBI gated QGSPECT, beside 3 patients whose images were not clear, studied for right ventricular size , so datum were acquired from 83 patients in this study. QGSPECT showed significant correlation for right ventricular size ( r=1.483+0.407X,r=0.643, P = 0.000 ). We divided the patients into two groups (1: RV 2.5cm group; 2: RV>2. 5cm group). The correlation of RV2.5cm group was more significant than that of the RV2.5cm group(l:r=0.537,P=0.000;2:r=0.257,P=0.420).Comparison with the consequence assessed by echocardiography, the hypothetic maximal of the right ventricular which was X+ S assessed by QGSPECT (Kappa =0.543) had a better agreement than that which was X+1.96S (Kappa=-0. 023).ConcIusion:(l).This study showed a good correlation as well as the agreement between 201TL gated SPECT and two-dimensional echocardiograms in measuring EF. Date of CO from SPECT was correlated well with that from echocardiography.(2).Right ventricular size determined by 99mTc -MIBI gated SPECT correlated closely with the echocardiography. However, there was poor correlation between gated SPECT and echocardiography regarding the RV dilation.(3) The hypothetic maximal of the right ventricular which was assessed by QGSPECT had good agreement with that assessed by echocardiography.
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