Experimental Repair Of Segmental Bone Defects In Rabbits By Demineralized Allograft Covered By Vasciularized Autogenous Periosteum

Objective To evaluate the effect of vasciularized autogenous periosteum combined with demineralized allograft in the treatment of bone defect of long bone.Methods The animal models of bilateral about 15mm radius bone defect were created by surgery in the big ear white rabbits,The effect were observed by gross, histopathological, electromicroscope scan and X- ray examinations, and were determined by biomechanics at 4,8.12 and 16 weeks.After operationResult By gross, histopathological ,electromicroscope scan, X-ray examinations and biomechanics, the effect indicated that the bone defect were perfectly repaired with vasciularized autogenous periosteum combined with demineralized allograft than demineralized allograft alone(p<0.05).Conclusion The effect of vascularized autogenous periosteum graft is better than that of demineralized allograft alone in the healing stage of the radius defects in rabbits. The vascularized periosteum combination therapy can promote the healing of bone defect rapidly and reliably.