The Clinical Study Of Xiao Cuo Jian In Acne Vulgaris And The Experimental Research On Its Mechanism

Acne vulgaris is the most common disorder treated by dermatologists. It is a disease of the pijosebaceous unit characterized by the formation of open and closed comedones, papules, pustules, nodules, and cysts. It is primarily a disease of adolescence, which occurs usually on the face and to a lesser\extent on the back, chest and shoulders. The exact etiology of acne is unknown, but a complex process involving sebaceousgland secretion, sebaceous gland blockage, inflammatory response (related to bacteria, especially Propionibacterium acnes), genetic factors, and environmental factors seems to be responsible.The therapy includes anti-keratinization, antibiotics and antiandrogen. But the incidence of side-effect must be considered.In Traditional Chinese Medicine (TCM) acne belongs to Lung-Wind comedones. It is considered to be caused by Damp-Heat in the Lung and Stomach. Therapentic methods include clearing away damp-heat from the lung and stomach and clearing away heat and removing toxin.Advisor QuZhuqiu has been dedicated in treatment of ance for many years. She believes that the pathogenic factors include kidney-fire, excessive fat, damp-heat and Qi-Xue attacting skin.Advisor Qu uses the methods of clearing kidney-fire, cooling blood, clearing away dampness and removing toxin, which is the treatment of the Primary and Secondary Symptoms simultaneously. The prescription "Xiao Cuo Jian " deriving from " Zhi Bai Di Huang Tang " is Phellodendron bark, Rhizoma Anemarrhenae, dried Rehmannia root, Moutan bark, Poria, oriental water plantain rhizome, red Sage root, Forsythia fruit, Chinese Violet, Dittany bark, Broom Cypress fruit, Dahurian Angelica root, etc. The emphasis of the formular's function is the concept of the Organism as a Whole and Diagnosis and Treatment Based n an overall Analysis of Signs and Symptoms. Its clinical effect is more efficient. So far no side-effect has been reported .In order to verify and explore the mechanism of the prescription, we carried out the study of this project. First, we did the bacteriostatic experiment with the powder. Second, an experimental model for acne to observe the anticomedone effect of the decoction is established. Third, an antiandrogen experiment is done.The conclusion shows that the prescription has bacteriostatic action, anti-keratinization action and antiandrogen action.