Clinical Analysis On Hypokalemic Tendency Of Graves' Disease And Its Association With HLA-DQA1 Gene Polymorphism

Part one: Clinical analysis of hypokalemic tendency in hyperthyroidism of Graves' diseaseObject: To analyze the clinical features and pathogenic mechanisms of hypokalemic tendency in Graves' disease.Methods: To screen and retrospectively analyze 378 cases of Graves' disease (GD) who were hospitalized in the General Hospital of Tianjin Medical University.Results: (1) The hypokalemic tendency in GD patients without exophthalmos and goiter seems to be much more frequently seen than that in GD patients with exophthalmos and/or goiter (P<0.01). (2) In GD patients without thyrotoxic periodic paralysis, it seems that hypokalemic tendency was more obvious in the female group than in the male (P<0.01). (3) In GD male group, serum potassium had no linear correlation with 24-hour uric potassium. In GD females with hypokalemic tendency, however, serum potassium had a significant negative linear correlation with 24-hour uric potassium (P<0.01) after potassium chloride was taken. (4) With serum 1,25(OH)D3 level and calcium intake amount unknown, hypokalemic tendency did not show any correlation with serum FT3 and FT4 levels, and 24-hour uric calcium.Conclusion: (1) GD patients without exophthalmos and goiter showed a significant hypokalemic tendency than those with exophthalmos and/or goiter. (2) In GD patients without thyrotoxic periodic paralysis, thepathogenic mechanism of hypokalemia is probably caused by the damages to renal tubule, leading to potassium leakage from kidney.